The possibilities of using retinol palmitate in the systemic treatment of generalized hereditary keratinization disorders

Hereditary ichthyosis is a group of generalized hereditary keratinization disorders characterized by general dryness the skin, peeling, hyperkeratosis and often erythroderma. These manifestations are caused mutations in genes mainly involved formation skin barrier. divided into syndromic non-syndromic. Nonsyndromic ichthyoses include: vulgar ichthyosis, recessive X-linked autosomal congenital keratinopathic other forms. At present, best result for achieving clinical remission has been established with oral retinoids: retinol palmitate, isotretinoin (1st generation retinoids) acitretin (2nd retinoids). The ability palmitate to regulate processes, strengthen epidermal barrier have an antioxidant effect used treatment disorders. Medium high therapeutic doses (200010 000 IU/kg/day) treatment. prescribed dose differs various nosological forms depends on severity pathological process, age weight patient, which must be taken account when prescribing therapy obtain result. It should noted that regress at do not lead appearance signs toxicity drug. methods ichthyosiform erythroderma described.